My father is 58 years old suffering from depression, for past 6-7 years & he is depressed due to my sister marriage. After treatment and medicines he become fit and fine. Later 1-2 year ago he becomes more active, aggressive and energetic than before, this behaviour remains for 1+ years. From last 5-6 months he again slowly gets into depression and becomes less active, does not talk much, keep tensed. Doctor prescribed half tablet of gatomir 15 (mirtazapine) at night and 1 tablet of zotral 50 (sertraline) at morning for 15 days. However 7+ days are past but he is not eating properly and we does not see much improvement. Can you please explain is it normal while taking anti depression medicines, and is this medicine is ok? Can we wait for some more time for improvement or we contact our doctor to change medicines?

Ms. Juhi ParasharPsychologist4yrs exp

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Hi lybrate-user, He is not suffering from Depression any more its taken form of Mania. A manic episode is characterized by period of at least 1 week where an elevated, expansive or unusually irritable mood, as well as notably persistent goal-directed activity is present. The mood disturbance associated with manic symptoms should be observable by others (e. G. Friends or relatives of the individual) and must be uncharacteristic of the individual?s usual state/behavior. These feelings must be sufficiently severe to cause difficulty or impairment in occupational, social, educational or other important functioning. Symptoms also cannot be the result of substance use or abuse (e. G. Alcohol, drugs, medications) or caused by a general medical condition. Three or more of the following symptoms must be present: Inflated self-esteem or grandiosity Decreased need for sleep (e. G. One feels rested after only 3 hours of sleep) More talkative than usual or pressure to keep talking Flight of ideas or subjective experience that thoughts are racing Attention is easily drawn to unimportant or irrelevant items Increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation Excessive involvement in pleasurable activities that have a high potential for painful consequences (e. G. Engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments). Now when the situation alters between episodes of depression and Mania it is called BIPOLAR MOOD DISORDER and it will need a fresh treatment. So I advise you to get the medication changed if it is not helping your father. 

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